Christ ALPHA 1-2 LDplus Manuale di Servizio

Operating Manual Freeze Dryer ALPHA 1-4 LSC Part. No. 102041 ALPHA 2-4 LSC Part. No. 102042 Version 09.2006 - English

Operating Manual Freeze Dryer ALPHA 1-4 LSC / ALPHA 2-4 LSC Enclosures • 91

92 • Enclosures Operating Manual Freeze Dryer ALPHA 1-4 LSC / ALPHA 2-4 LSC

Operating Manual Freeze Dryer ALPHA 1-4 LSC / ALPHA 2-4 LSC Enclosures • 93

94 • Enclosures Operating Manual Freeze Dryer ALPHA 1-4 LSC / ALPHA 2-4 LSC

96 • Enclosures Operating Manual Freeze Dryer ALPHA 1-4 LSC / ALPHA 2-4 LSC

98 • Enclosures Operating Manual Freeze Dryer ALPHA 1-4 LSC / ALPHA 2-4 LSC

1. General Information 1.1. Introduction What is freeze drying (lyophilisation)? Freeze drying means: Extraction of water from frozen material. The d

100 • Enclosures Operating Manual Freeze Dryer ALPHA 1-4 LSC / ALPHA 2-4 LSC

10. Special functions

NetzschalterAnlagensteuerung LSCEiskondensatorkammerBelüftungsventilEiskondensatorAblassventilVakuumanschlussAnschluss Spannungsversorgung Drucksteuer

1.2. Areas of application The freeze dryer ALPHA 1-4 LSC / ALPHA 2-4 LSC is a high-performance universal laboratory and pre-production unit for free

1.3. Technical data of freeze dryer ALPHA 1-4 LSC / ALPHA 2-4 LSC Performance data ALPHA 1-4 LSC ALPHA 2-4 LSC Ice condenser capacity: 4 kg

Performance data ALPHA 1-4 LSC ALPHA 2-4 LSC Drying in round-bottom flasks; please notice that the max. ice condenser capacity is 4 kg (process B)

Performance data ALPHA 1-4 LSC ALPHA 2-4 LSC Main fuse rating: 10.0 A 12.0 A Ambient temperature1): +10°C to +25°C (higher temperatures upon r

1.4. Standards and regulations Please refer to the enclosed EU Declaration of Conformity. 1.5. Safety instructions 1.5.1. CAUTION! Disconnect the m

1.5.5. NOTE! Transport instructions! Please keep the packaging for possible subsequent dispatch. The freeze dryer should be carried by two persons

1.6. Prohibited freeze drying processes 1. Operation of the freeze dryer when it is not properly installed. 2. Operation of the freeze dryer with

2. General Information on Freeze Drying 2.1. General Information on Freeze Drying Freeze drying is the gentlest process for drying products. It is b

Sublimation The principle of sublimation is briefly explained using the phase diagram of water (freeze drying of mainly aqueous solutions, see vapor

Conversion table "Vapor pressure above ice" (sublimation curve) Pressure units: 1mbar = 100Pa 1Pa = 0.01mbar Temperature units: 273+=t

2.2. Preparation In case the unit is equipped with a pressure control valve the vacuum pump should be warmed up. The operating temperature should be

Freezing inside the unit is not necessary if the product is pre-frozen or stored in e. g. a deep-freeze. In this case, especially when freeze dryin

Warning: Acidic products or products with a high solvent concentration cannot be dried without special safety measures and devices, such as an additi

During the main drying phase the moisture is removed by sublimation, during final drying the bound moisture is removed by desorption. This small quan

The drying time depends heavily on the drying vacuum. The nearer the vacuum to the solidification point in accordance with the vapor pressure curve

Heat transfer takes place via the heated shelves by direct contact with the bottom of the vessel and/or by convection via the shelf and vessel or pr

2.6. End of drying and aeration A rough indication of the end of drying is the vacuum and the ice condenser temperature. The ice condenser is no lon

3. Description of the Freeze Drying Processes 3.1. Freezing and drying inside the ice condenser chamber (process A) on a temperature-controlled shel

OPERATING MANUAL ALPHA 1-4 LSC / ALPHA 2-4 LSC Order Number: Serial Number: In case of inquiries please state the above numbers.

In order to seal the bottles, the shelf must be completely filled. For small quantities, at least three spacers must be distributed evenly on each sh

To control the shelf temperature, one shelf with a measuring sensor has to be connected. The plug of the shelf with the measuring sensor has to be co

3.3. Separate freezing and drying outside the ice condenser chamber (process B) with sealing device Possible water residue is removed from the ice c

3.4. Separate freezing and drying of liquids in flasks (process B) Possible water residue is removed from the ice condenser chamber. The drain valv

Using a distributor, a maximum of 15 ampoules can be simultaneously frozen in the cooling bath and connected to the manifold. 3.5. Separate freezing

4. Installation and Commissioning of the Unit 4.1. Site of installation ATTENTION! In order to ensure the air circulation of the heat exchanger, do

The following connections are required at the site: 4.2. Mains power The operating voltage on the name plate must correspond to the local supply volt

4.7. Vacuum pump exhaust gases During the main drying phase, the separate vacuum pump must be operated with open gas ballast valve. The oil mist tha

4.8. Initial start-up ATTENTION! Prior to start-up, make sure that the freeze dryer has been properly set up and installed (see section 4.1 “Site of

4.8.2. Vacuum sensor, vacuum pump and pressure control valve connection Connection diagram Process A (single-chamber system): Freezing and gentle

The accessory components are connected to the ALPHA 1-4 LSC / ALPHA 2-4 LSC freeze dryer according to the connection diagram. Please observe the foll

Installation of the VSP62 vacuum sensor The vacuum sensor has to be connected to the vacuum connection at the back of the unit in an upright position

Installation of the vacuum pump The vacuum pump has to be connected to the unit and to the socket at the back panel of the unit. Make sure that the

4.8.3. Installation of accessory components Further accessories (e.g. shelves, connections for round-bottom flasks) are added in accordance with the

Process B 34 • Installation and Commissioning of the Unit Operating Manual Freeze Dryer ALPHA 1-4 LSC / ALPHA 2-4 LSC

Process B Connection piece for rubber valve to extend the drying chamber, 18 pieces max. Drying vessel, e.g. round bot

Process B Ground-in stopperRack with 10 shelves mØ200mm ax., Drying chamber Ø300mm Base plateALPHA 1-4 LSC ALPHA 2-4 LSC 3

Process A Acrylic lid Shelf Ø200 Sealing device ALPHA 1-4 LSC ALPHA 2-4 LSC Drying vessel, e.g. injection bottle 4.8.4. Preparati

5. LSC Control System 5.1. Introduction LSC (Lyo Screen Control) stands for a graphical user interface that is used to control freeze drying process

Preface Dear customer Congratulations on purchasing a CHRIST freeze dryer. The freeze dryer ALPHA 1-4 LSC / ALPHA 2-4 LSC is equipped with a lot of u

5.1.2. Brief description of operation The LSC control system is operated via the central turn & push button and four function keys at both side

5.2. Visual components of the LSC control system The LC display is divided into the three following areas: • Menu bar • Window area • Status bar F

Press the button to confirm the selected menu. Fig. 4 Selected focus in the menu bar The system opens a pop-up menu or a new window. Fig. 5 Pr

5.2.3. Pop-up menus There are two different types of pop-up menus: Pop-up menus that are opened by selecting one of the main menu tabs (first-level

equipment information system is an exception since this dialog box is opened automatically by the system. Fig. 8 Dialog box The following control e

The lower part of the window shows an animated mimic diagram with active components (symbols). The active components of the unit are the ice condens

Values window The values window compares set values and actual values of the running process in a clear manner. Fig. 14 Values window The display

The following actual values can be selected via the sub-scrollbar: - Time h:min (current time) - Tot. h:min (total process time) - Sec. h:min (tim

5.3. Function keys Function key “Standby” The function key “Standby” is used to switch off all aggregates. This function is always available (from

Fig. 18 Dialog box “Device locked!“ The control panel can be unlocked by pressing the function key again for 2 seconds. Function key “°C≙mbar”

switch manually to the next phase without setting the unit to the standby mode. When all desired phases are finished – usually after the final drying

Fig. 21 Dialog box for the input of set values in the manual mode To enter set values, select the corresponding nominal value set (phase) from the

5.4.3. Set values for manual main drying and final drying Fig. 25 Nominal value set for main drying and final drying The set values “vacuum” and

automatically after the set defrosting time (see VALUES Æ Set Values for Manual Mode). It is not possible to start the defrosting phase during an act

Pressure difference = actual vacuum value at the beginning of the measurement - current actual vacuum value Fig.28 Intermediate valve betwe

5.5. Programmer module (optional) 5.5.1. General information The programmer module PGM-30 is used for a timer-controlled pre-programmed process (free

warm-up phase. As a result, the pressure inside the chamber is not affected. Fig. 31 The programmer module shifts the warm-up phase into the freezi

5.5.2. Creating a new Program In order to create a new program, select a free location under Program Æ New. Free program locations are marked by &l

entered. The user code is defined under OPTIONS Æ Misc. Æ Security. Fig. 35 Dialog box for entering the user code The programmer module always show

exit the editing frame, select the top focus position (section number). Inserting a section This button inserts a new section at the section posit

Contents 1. General Information 1 1.1. Introduction ...

Fig. 37 General program information 5.5.4. Loading a program Select the program under PROGRAM Æ Load. A dialog box opens showing general program in

5.5.5. Copying a program Select the program to be copied (source program location) under PPROGRAM Æ Copy. Only program locations that actually contai

5.5.7. Delta t freezing/drying Preselection of the maximum admissible difference between the shelf temperature and the product temperature at the en

Test time During the test, the ice condenser is separated from the drying chamber. The pressure increase is analyzed after the test time. If the pre

Fig. 43: Dialog box for the process and equipment information system The following messages are displayed in the process and equipmen

This error message is displayed if the program fails to perform two successful pressure increase measurements in a row at the end of a section. The s

5.7. Options The OPTIONS menu is used to enter elementary configurations of the control system. Fig. 44 Options menu 5.7.1. Info Select the menu

Fig. 45 Dialog box for setting the contrast 5.7.3. Language To set a language, select OPTIONS Æ Language. Turn the turn & push button to sele

Set the current values for day, month and year und confirm these settings with . To set the time, proceed as follows: Set the current values for ho

5.7.6. Maintenance intervals of the vacuum pump The maintenance intervals of the vacuum pump can be defined and reset under OPTIONS Æ Misc. Æ Vacuum

5. LSC Control System 39 5.1. Introduction ...39 5

Fig. 51 Mimic diagram process A Fig. 52 Mimic diagram process B 5.7.8. Unlocking This dialog box can be opened under OPTIONS Æ Misc. Æ Unlock. A

Fig. 54 Dialog box for entering the old user code There will be a long sound signal (about 1 s) if a wrong user code is entered. If the user code i

Two calibrations are possible: the calibration of the IO sensor card and the calibration of external measuring modules (Pirani and Lyo Control). LSC

6. Troubleshooting 6.1. Power failure The control system continues with the process after a power failure. The pre-selected conditions remain saved e

Please proceed in the same way in case of a leak in the aeration valve. Check the lid seal for dirt or damage. If necessary, it must be cleaned or r

Check the internal fuse 202F3. 6.4. Heating unit is not activated Please note that during the main drying phase and during the final drying phase th

The refrigeration unit is automatically switched off in these cases. Once the permissible operating conditions are reached again (after a few minutes

Code 04 Excess temperature “ice condenser”. Temperature “ice condenser” is 65°C or more! Freeze Dryer was switched into Standby. This error occurs wh

Code 29 See chapter 5.6.1. Code 30 Note: Error in configuration memory. Please verify user defined parameters and check the back-up battery. This er

Code 36 AC power failure L2 Power failure in phase L2. Please check the on-site fuses. Code 37 AC power failure L3 Power failure in phase L3. Ple

7.5. Vacuum pump...83 7.6. Exhaust filter ...

This error message is displayed, if the temperature sensor is either not connected or defective. Please call customer service. 80 • Troubleshooting

7. Maintenance 7.1. Ice condenser chamber Before each start-up, ensure that all water residues have been removed from the ice condenser chamber. If

A freeze dryer should be aerated and the dry product should be removed at the end of the drying process. Then the system should be defrosted with war

Calibration to a specific zero reference value: To perform the calibration, the actual pressure must be lower than 1.0x10-2 mbar. After pressing of

7.6. Exhaust filter If the unit is equipped with an exhaust filter (necessary if the exhaust gases cannot be extracted into the open air or into a ve

If there is the risk of toxic, radioactive or pathogenic contamination, special safety measures must be considered and adhered to. Aluminium accesso

7.7.5. Checks by the operator The operator has to ensure that the important parts of the freeze dryer that are necessary for safety are not damaged

8. Options 8.1. Process control system LPC-32, software 8.2. Process control system LPC-32, software with PC hardware 8.3. Programmer module PGM

8.8. Electrical lifting device Only for ALPHA 1-4/2-4 LSC GAMMA 1-16 LSC / 2-16 LSC and DELTA 1-24 LSC / 2-24 LSC ALPHA 1-4/2-4 LDplus BETA 1-8/2-8

9. Enclosures Declaration of conformity ALPHA 1-4 / ALPHA 2-4 LSC Operating manual of the vacuum pump (only in case of delivery) Operating manual